Mesodermal expression of Moz is necessary for cardiac septum development

Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development.

The development of the segmented pharyngeal apparatus involves complex interaction of tissues derived from all three germ layers. The role of mesoderm is the least studied, perhaps because of its apparent lack of anatomical boundaries and positionally restricted gene expression. Here, we report that the mesoderm-specific deletion of Tbx1, a T-box transcription factor, caused severe pharyngeal p...

XMeis3 Is Necessary for Mesodermal Hox Gene Expression and Function

Hox transcription factors provide positional information during patterning of the anteroposterior axis. Hox transcription factors can co-operatively bind with PBC-class co-factors, enhancing specificity and affinity for their appropriate binding sites. The nuclear localisation of these co-factors is regulated by the Meis-class of homeodomain proteins. During development of the zebrafish hindbra...

Continued Expression of GATA3 Is Necessary for Cochlear Neurosensory Development

Hair cells of the developing mammalian inner ear are progressively defined through cell fate restriction. This process culminates in the expression of the bHLH transcription factor Atoh1, which is necessary for differentiation of hair cells, but not for their specification. Loss of several genes will disrupt ear morphogenesis or arrest of neurosensory epithelia development. We previously showed...

“Rhetoric Teaching” is necessary for all of the university students?

A simple search for information sources shows that there are many researches and articles in the field of lecture method and comparison with other types of teaching methods. Interestingly enough, if not with certainty in all of these researches, at least in most of them, the result was in favor of non-lecturing. Previously, the authors emphasized the importance of rhetoric in a Persian letter (...

Is cardiac rehabilitation necessary?